منابع مشابه
Ex vivo expansion of hematopoietic cells and their clinical use.
BACKGROUND AND OBJECTIVE Hematopoietic stem cells are being increasingly used for treatment of malignant and nonmalignant disorders. Various attempts have been made in recent years to expand and manipulate these cells in order to increase their therapeutic potential. A Working Group on Hematopoietic Cells has analyzed the most recent advances in this field. EVIDENCE AND INFORMATION SOURCES Th...
متن کاملHematopoietic growth factors: ESMO Clinical Practice Guidelines for the applications.
Despite relatively high rates of low neutrophil count during standard-dose chemotherapy regimens for malignancies other than acute leukaemias, rates of FN, other complication rates and mortality rates are relatively low for most standard chemotherapies (Table 1). These rates do not justify the systematic use of haematopoietic growth factors (hGFs) such as granulocyte colony-stimulating factor (...
متن کاملEarly-acting hematopoietic growth factors: biology and clinical experience.
Secreted protein growth factors that stimulate the self-renewal, proliferation, and differentiation of the most primitive stem cells are among the most biologically interesting molecules and at least theoretically have diverse applications in the evolving field of regenerative medicine. Among this class of regulators, the early-acting hematopoietic growth factors and their cellular targets are ...
متن کاملclinical use of statins in hematopoietic stem cell transplantation: old drugs and new horizons
hydroxymethylglutaryl co-enzyme a reductase inhibitors, also known as statins, are a class of anti-hyperlipidemic agents. these drugs have been employed vastly to reduce the morbidity and mortality of cardiovascular disorders. soon after their introduction, benefits other than their primary actions were discovered. along with these pleiotropic properties, a series of mainly favorable effects ha...
متن کاملHematopoietic growth factors
Erythropoietin is a lineage-specific distal-acting factor that stimulates maturation of committed erythroid progenitors to become mature erythrocytes.3 Carbohydrates, rich in sialic acid, make up 30% to 40% of the 34,000-Da molecule and are essential for its secretion, stability in the circulation, and biologic activity. Many earlier-acting factors, including stem cell factor/kit ligand, interl...
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ژورنال
عنوان ژورنال: SEIBUTSU BUTSURI KAGAKU
سال: 1989
ISSN: 0031-9082,1349-9785
DOI: 10.2198/sbk.33.17